Endocrine Abstracts

30 years old female with history of sinusitis, anxiety states, diagnosed with relapsing multiple sclerosis from May 2005, initially had abnormal sensation and weakness of left side of body with MRI finding of demyelinating lesion in the cervical cord, treated with i/v methyl prednisolone with good recovery. Unfortunately had multiple relapses, therefore treated with two doses of Alemtuzumab since June 2012, presented with shakiness and a rash in her neck in July 2012. Clinical...

A 73-year-old female, fit and well otherwise, was not any regular medications, was diagnosed with choroidal melanoma in 2010, and enucleated, subsequently had DTIC for multiple metastasis in 2014. She also received ipilimumab for 3 months as second line treatment for metastases. Presented to neurosurgeons with cold intolerance and dizzy spells, random cortisol was <30, started on dexamethasone 1 mg twice daily. Also had a low TSH of 0.71 with low free T4. Short ...

Case history: PD is a 57-year-old female teacher who presented to her GP in October 2017 with lethargy, dyspnoea and anaemia. Bone marrow biopsy followed by a CT scan of her chest and abdomen confirmed lobular breast cancer with peritoneal and bone metastases (ER+/HER2−). The patient also had an MRI scan of her head to assess for intracranial metastatic disease which was negative at the start of December 2017. She was commenced on letrozole, palbociclib and denosumab. A ...

Aim: Over the last decade, cardiac valvular fibrosis has been associated with the use of high dose (ergot-derived) dopamine agonist therapy in Parkinson’s disease. Although the risk in endocrine patients appears significantly lower, routine echocardiographic monitoring is now recommended. This study evaluated the incidence of significant cardiac valvulopathy in endocrine patients treated with cabergoline in a District General Hospital Population, and compliance with MHRA ...

A 32-years-old lady was admitted with raised calcium. She had palpitation, sweating, 3 stones weight loss and neck swelling. She was diagnosed with Graves’ disease 5 months ago. Her mother had history of thyroid disease but no family history of hypercalcaemia. She had a small goitre and lid lag on examination. On admission, adjusted calcium was 3.04 mmol/l. PTH was < 0.5 pmol/l. Phosphate, vitamin-D, kidney functions, cortisol, myeloma screen and ACE levels ...

Case history: A 61 year old male with a background of diabetes mellitus Type 2 and congestive cardiac failure (CCF) was diagnosed with Cushing’s disease in 2014 following identification of severe osteoporosis through investigations for non-traumatic vertebral fractures causing paraplegia.Investigations: He had high ACTH and cortisol levels which failed to suppress on low and high dose dexamethasone suppression tests, hypogonadotrophic hypogonadism a...

Case report: A 52-year-old woman presented with an 11-month history of increasing hirsutism and deepening voice. She had a past history of total abdominal hysterectomy (ovaries preserved) with adjuvant chemotherapy and radiotherapy for cervical carcinoma. She was on no medication. Examination revealed evidence of virilisation with no other abnormality.Investigations: Total testosterone=10.7 nmol/l (<2.9).FSH=31.7 U/l (37–1...

Background: Hypothyroidism is reported to be associated with mild insulin resistance though severe insulin resistance is rare. We report the case of a man presented with reversible severe insulin resistance in hypothyroidism.Case report: A 23-year-old obese man with autism was presented with poor responsiveness (GCS 7/15). He had general malaise for 2 days prior to admission. On admission, his test results showed random glucose – 60.8 mmol/l, potass...

Section 1: A 77 year female was referred by her GP in May 2019 for abnormal thyroid function tests (TFT) which were requested due to new diagnosis of atrial fibrillation. The patient was otherwise asymptomatic and clinically euthyroid. Family History was negative for thyroid abnormalities. On enquiry, the patient revealed that she had abnormal thyroid function tests associated with a large goitre in 1970s and subsequently underwent partial thyroidectomy followed by radioactive...

Section 1: Case history: A 61-year-old lady was referred by her GP to our endocrine clinic with abnormal thyroid function tests (TFTs) incidentally identified in routine blood tests. She had no symptoms suggestive of thyrotoxicosis apart from occasional palpitations when using inhalers for asthma. She had no family history of endocrine significance. She was on salbutamol, salmeterol, fluticasone inhalers and laxatives. Physical examination was unremarkable with no goitre. ...